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Table 5 CEA with a health outcome: cost per HIV infection averted

From: Cost-effectiveness analyses of training: a manager’s guide

 

Pre-training

Post-training

Program cost

  

Remuneration

  

Clinical staff, including counselors

$65,000

$72,000

Supervisory staff

$15,000

$12,000

Total remuneration

$80,000

$84,000

Supplies, including HIV test kits and ARV drugs

$15,000

$18,000

Capital (annuitized)

  

Vehicle

$3,000

$3,000

Equipment

$500

$500

Building

$1,500

$1,500

Training

$0

$5,000

Total Capital

$5,000

$10,000

Total program cost

$100,000

$112,000

Estimate of effectiveness

  

Number of mother infant pairs that PMTCT

1000

1200

Estimated vertical HIV transmission before and at birth*

  

Base case 

25%

25%

Lower bound 

19%

19%

Upper bound 

30%

30%

Effectiveness of regimen for mothers and infant

63%

63%

Estimated HIV infections averted

  

 Base case

(1000*.25*.63) =158

(1000*.25*.63) =189

 Lower bound

120

144

 Upper bound

189

227

Cost-effectiveness analysis

  

Incremental cost

($112,000-$100,000) = $12,000

Incremental HIV infection averted

  

 Base case

 

(189–158) = 31

 Lower bound

 

(144–120) = 24

 Upper bound

 

(227–189) = 38

Incremental cost-effectiveness ratio (ICER)

  

 Base case

 

($12,000/31)=$283

 Lower bound

 

$215

 Upper bound

 

$340

  1. *The effect of the training on MTCT is uncertain because there is a range of estimates for vertical HIV transmission before and during birth. The midpoint of the range is used to estimate effectiveness for the base case, and a sensitivity analysis is conducted with the lower and upper bounds. The base case and range are also reported for the number of HIV infections averted and ICER.