Skip to main content

Equivalence between physicians and associate clinicians in the frequency of iatrogenic urogenital fistula following cesarean section in Tanzania and Malawi

Abstract

Background

Physicians and associate (non-physician) clinicians conduct cesarean sections in Tanzania and Malawi. Urogenital fistulas may occur as complications of cesarean section. Location and circumstances can indicate iatrogenic origin as opposed to ischemic injury following prolonged, obstructed labor.

Methods

This retrospective review assessed the frequency of iatrogenic urogenital fistulas following cesarean sections conducted by either associate clinicians or physicians in Tanzania and Malawi. It focuses on 325 women with iatrogenic fistulas among 1290 women who had fistulas after cesarean birth in Tanzania and Malawi between 1994 and 2017. An equivalence test compared the proportion of iatrogenic fistulas after cesarean sections performed by associate clinicians and physicians (equivalence margin = 0.135). Logistic regression was used to model the occurrence of iatrogenic fistula after cesarean section, controlling for cadre, date, maternal age, previous abdominal surgery and parity.

Results

Associate clinicians attended 1119/1290 (86.7%) cesarean births leading to fistulas, while physicians attended 171/1290 (13.3%). Iatrogenic fistulas occurred in 275/1119 (24.6%) cesarean births by associate clinicians and in 50/171 (29.2%) cesarean births by physicians. The risk difference and 90% confidence interval were entirely contained within an equivalence margin of 13.5%, supporting a conclusion of equivalence between the two cadres. The odds of iatrogenic fistula after cesarean section were not statistically significantly different between associate clinicians and physicians (aOR 0.90; 95% CI 0.61–1.33).

Conclusions

Associate clinicians appear equivalent to physicians performing cesarean sections in terms of iatrogenic fistula risk. Lower iatrogenic proportions for associate clinicians could reflect different caseloads. The occurrence of iatrogenic fistulas illustrates the importance of appropriate labor management and cesarean section decision-making, irrespective of health provider cadre. Given the noninferior performance and lower costs of employing associate clinicians, other countries with insufficient and/or unequally distributed health workforces could consider task-shifting cesarean sections to associate clinicians.

Peer Review reports

Background

Two-thirds of global maternal deaths occur in sub-Saharan Africa, largely due to preventable and treatable complications such as hypertensive disorders, obstetric hemorrhage and maternal sepsis [1, 2]. Ensuring maternal and neonatal survival requires comprehensive emergency obstetric and newborn care for mothers experiencing life-threatening complications during childbirth [3]. Comprehensive emergency obstetric and newborn care encompasses basic obstetric care as well as safe blood transfusion, advanced newborn resuscitation and cesarean section.

When indicated, cesarean sections save maternal and newborn lives, particularly in countries with low cesarean section rates and high maternal mortality ratios [4, 5]. Compared with vaginal birth, cesarean sections are associated with greater risks of maternal and perinatal death and newborn sepsis as well as maternal morbidity from abnormal invasive placentation and uterine scar rupture in subsequent pregnancies [6,7,8,9]. In remote and under-resourced areas, the risks associated with cesarean birth differ significantly, with maternal mortality after cesarean birth being 50 times greater in sub-Saharan Africa compared to high-income settings [10]. Cesarean births constitute nearly one-third of all surgeries in resource-poor settings [11].

The availability of quality cesarean sections depends upon trained caregivers. Yet, the number of available healthcare workers is lowest in places where healthcare workers are most needed. Globally, the shortage of human resources for health is most acute in sub-Saharan Africa, where the World Health Organization reports that 36 countries face a critical shortage of doctors, nurses and midwives [12, 13]. Many countries are training increasing numbers of clinicians in response to the clear needs of growing populations. At national and sub-national levels, health personnel are concentrated in urban areas and are insufficiently distributed in rural, low-resource areas where maternal mortality and morbidity are highest [14].

To address the challenges in the number and distribution of physicians, many countries deploy associate clinicians, non-physicians who take on many of the diagnostic and clinical functions of doctors [15]. With various titles including assistant medical officers, clinical officers, health officers, medical assistants and physician assistants, associate clinicians were active in 25 of 47 sub-Saharan African countries in 2007 [15]. Tanzania and Malawi use task shifting to expand obstetric surgical capacity: associate clinicians are authorized and trained to perform cesarean sections and other major emergency obstetric surgeries [16]. They are two of six countries in sub-Saharan Africa where associate clinicians perform cesarean sections; others are Ethiopia, Ghana, Mozambique and Sierra Leone [15, 17, 18].

Associate clinicians have training beyond secondary school, typically with more clinical skills than nurses but fewer than doctors [15]. Associate clinician training focuses on diagnosis and medical treatment, including prescribing medications. Associate clinicians in Malawi and Tanzania typically do not have a university qualification before completing at least three years of medical training and being licensed to provide general medical care [15]. In contrast, physicians (medical officers) in Malawi and Tanzania complete 5 years of medical training and an internship in medicine, pediatrics, surgery and obstetrics/gynecology [19]. Physician training typically includes greater emphasis on basic anatomy, physiology and pathology, advanced technology and hospital-based care [15].

Task shifting represents a strategic response to substantial workforce volume and distribution challenges in both countries. In 2018, Tanzania had an estimated one physician for 17 544 people, while Malawi had one physician for 71 429 people [12]. Maternal mortality has declined substantially in both countries yet remains a persistent challenge. According to 2020 estimates from the World Health Organization, the maternal mortality ratio was 238 deaths per 100 000 live births in Tanzania and 381 deaths per 100 000 live births in Malawi [20].

Associate clinicians have been central to improve staffing for essential surgery in places where they are authorized and trained to provide comprehensive emergency obstetric and newborn care [21]. Although task shifting to associate clinicians can improve mothers’ access to emergency obstetric care, physicians in many countries remain skeptical about associate clinicians providing cesarean sections [15, 22]. Despite documentation regarding the feasibility and outcomes of task shifting for cesarean sections, this strategy has not been widely embraced by other countries experiencing human resource crises and high maternal mortality [21]. Ongoing evidence-generation and communication are therefore useful for informing policymakers who may be considering expanding the cadres that are authorized and trained to provide cesarean sections.

This review uses a data set of women who presented for urogenital fistula repair to consider the circumstances of fistula development. Urogenital fistulas may occur between any part of the genital tract and nearby organs in the pelvis, including the bladder or rectum. Women with urogenital fistulas suffer from urinary and/or fecal incontinence. Most urogenital fistulas are ischemic and are caused by pressure necrosis when women in neglected prolonged (obstructed) labor are not able to undergo emergency cesarean section in time. Fistulas can also be iatrogenic, arising as surgical accidents during obstetric or gynecological surgery. Cesarean birth is becoming more frequent as the mode of birth that is reported by women who have developed fistulas and sought fistula repair [23]. The occurrence of iatrogenic fistulas during cesarean birth is a sentinel event reflecting the overall quality of surgical care [24, 25]. A variety of outcomes could be used to assess cesarean section quality. Given the availability of retrospective data from women seeking fistula repair, this analysis compares the frequency of iatrogenic urogenital fistulas following cesarean section performed by physicians and associate clinicians in Tanzania and Malawi.

Methods

This retrospective records review evaluated the frequency of cesarean-associated iatrogenic fistulas by cadre among 1290 women who presented with fistula-related incontinence after cesarean birth in Tanzania and Malawi. These women are a subset of a larger group of 6787 women who presented for fistula repair in nine countries [25, 26]. As detailed elsewhere, TJIPR, MM, and their colleagues collected data between June 1994 and December 2017 [27]. One of the surgeons interviewed the women and recorded information on a standard form, documenting the woman’s age at presentation, age at fistula development, obstetric history (including previous births and previous laparotomies) and mode of birth [27]. Women provided information about the condition of the newborn at birth. The operating surgeon noted the fistula’s classification based on Waaldijk’s classification system, which categorizes fistulas based on their anatomic/physiologic position, involvement of the closing mechanism and urethra, and whether the damage is circumferential [28]. TJIPR examined all women and reviewed and verified all fistula classifications and operations.

Women seeking fistula repair in Tanzania and Malawi were interviewed in 36 facilities, largely district and mission hospitals. Two-thirds of these facilities where fistulas were repaired were in rural areas. Women had developed fistulas following cesarean section in an unknown, larger number of hospitals some time before seeking repair. Detailed information regarding these facilities is not available.

TJIPR noted the cadre of the health provider who performed the cesarean section on the basis of the description provided by the woman and his knowledge of local facilities and staffing, which was complemented by input from local staff. This analysis groups all physicians, including medical officers and those with additional training, such as registrars (residents) and specialists (who have completed residency in obstetrics and gynecology). Associate clinicians are called assistant medical officers in Tanzania and clinical officers in Malawi.

Women seeking fistula repair in Tanzania or Malawi from TJIPR, MM and colleagues were eligible for inclusion in this analysis if they had a fistula following cesarean section, cesarean hysterectomy or uterine rupture repair, grouped together as “cesarean birth.” All cesareans were emergency procedures that occurred during labor. Women were excluded if they developed fistulas following vaginal birth, gynecological surgery, traumatic injury (from accidents, traditional healers or sexual violence), abortion or radiation. Women were also excluded if their causative births occurred before 1994.

Fistula origin can be ambiguous in cases where women labor for a long time before cesarean section. This analysis follows previously proposed definitions for the likelihood of iatrogenic etiology [19]. “Definitely iatrogenic” fistulas occur away from where fetal head pressure against the mother’s pelvis would lead to ischemia and necrosis. This category includes ureteric injuries, which arise from an inadvertent nick, cut or tie of the distal ureter near the cervix where it is crossed by uterine vessels [29]. This category also includes vesico-cervico-vaginal fistulas following the cesarean birth of a live baby, as the cesarean birth of a live baby is rarely associated with pressure necrosis. “Probably iatrogenic” fistulas further include vault fistulas following cesarean-hysterectomy. A vault fistula is a connection between the bladder and the top of the vagina after total removal of the uterus, most often for a ruptured uterus. However, fistulas should not be considered iatrogenic in cases where bladder rupture occurs. “Likely iatrogenic” fistulas further include vesico-cervico-vaginal fistulas following cesarean birth with stillbirth, as long as the fistulas are small (< 3 cm), clearly in the cervical canal, and without bladder rupture. Fistulas not meeting the above criteria were not considered to be iatrogenic. TJIPR applied these criteria to determine the origin of fistulas for all included records on the basis of his examination and the surgical notes. A previous analysis applied these definitions to assess the rise in iatrogenic fistulas after cesarean section in nine African countries [25].

Data were entered into an Excel database, with names changed to unique identification numbers to protect privacy. Data were analyzed using Stata 16 software (StataCorp). Country-specific logistic regressions were used to model iatrogenic fistulas among cesarean births resulting in fistula by cadre (physicians and associate clinicians). The models included the year of fistula development, age at fistula development, parity and previous abdominal surgery (nearly always a cesarean birth). We used categories for fistula development dates (1994–1999 as a reference, 2000–2004, 2005–2009 and 2010–2017), parities (1, 2, 3–5, 6+), and age at fistula development (11–19 as a reference, 20–24, 25–29, 30–34, 35+). The threshold for statistical significance was p < 0.05.

Equivalence testing is more appropriate than traditional statistical tests of differences (such as ANOVA and t tests) in cases where the goal is to demonstrate similarity between approaches. Equivalence testing reverses the traditional null and alternative hypotheses, such that the null hypothesis is that the two approaches are not equivalent [30, 31]. In this case, our null hypothesis was that the difference in the risk of iatrogenic fistula after cesarean birth was not equivalent between associate clinicians and physicians, as measured by a generalized linear model. The equivalence region, δ, was defined as a 13.5% difference in means in iatrogenic fistula occurrence between cesarean births performed by associate clinicians and physicians. An observed difference within this definition would therefore be considered evidence of equivalence between the two cadres. Equivalence testing involves two one-sided tests (TOSTs), each carried out at a statistical significance level of p < 0.05. As such, the confidence interval was (1-2α) × 100% or 90%.

Results

Associate clinicians performed 1119/1290 (86.7%) of the cesarean births leading to fistulas, including 86.0% (833/969) in Tanzania and 89.1% (286/321) in Malawi (Table 1). One-quarter of genital fistulas following cesarean birth were iatrogenic in both Tanzania (242/970, 25.0%) and Malawi (83/321, 25.9%). An iatrogenic fistula occurred in 275/1119 (24.6%) of cesarean births by associate clinicians compared to 50/171 (29.2%) of cesarean births by physicians (Table 2). Stillbirths occurred in 1035/1287 (80.4%) of the cesarean births leading to fistulas.

Table 1 Cadre attending cesarean birth leading to fistulas
Table 2 Iatrogenic fistula occurrence by attending cadre

Combined and country-specific logistic regressions are provided in Table 3. Controlling for date, age, parity and previous abdominal surgery, the odds of iatrogenic fistula after cesarean section were not statistically significantly different between associate clinicians and physicians, neither overall (aOR 0.90; 95% CI 0.61–1.33) nor in Tanzania (aOR 0.80; 95% CI 0.51–1.24) nor in Malawi (aOR 1.44; 95% CI 0.65–3.17).

Table 3 Logistic regression of iatrogenic fistulas among cesarean births resulting in fistulas

The factors associated with iatrogenic fistula etiology after cesarean section were directionally similar between Tanzania and Malawi, although they were more often statistically significant in Tanzania than Malawi due at least in part to Tanzania’s larger sample size. While the odds of iatrogenic origin among cesarean births resulting in fistula remained steady between 1994 and 2017 according to the 2 × 2 comparison, the date of fistula development was statistically significant in models controlling for other variables (aOR 0.19–0.22, 95% CI 0.13–0.31). The odds of iatrogenic fistula more than doubled in women who reported previous abdominal surgery (aOR 2.48, 95% CI 1.67–3.69), with a more pronounced and statistically significant effect in Tanzania (aOR 2.83; 95% CI 1.80–4.48) than in Malawi (aOR 1.78; 95% CI 0.77–4.08). The odds of iatrogenic fistula increased with increasing parity: aOR 2.36 (95% CI 1.49–3.72) at para 2, aOR 2.58 (95% CI 1.57–4.24) at para 3–5 and aOR 4.20 (95% CI 2.29–7.70) at para 6 or more. Age was not generally associated with increased odds of iatrogenic etiology in this modeling.

A generalized linear model was used to assess the risk difference (0.0467) and 90% confidence interval (− 0.014, 0.107) between the two cadres for iatrogenic fistula following cesarean birth. The 90% confidence interval was entirely contained within the margins of equivalence (− 0.135, 0.135), providing evidence of equivalence between cadres.

Discussion

Tanzania and Malawi are among the six African countries where associate clinicians perform cesarean sections, particularly in rural areas where the number of doctors is insufficient [16]. This analysis revealed that during the period of 1994–2017, associate clinicians in Tanzania and Malawi were equivalent to physicians in terms of the proportion of iatrogenic fistulas occurring during cesarean birth at an equivalence margin of 13.5%. We are not aware of other evidence on cadre and iatrogenic fistulas following cesarean section from the six countries with cesarean task shifting. Our findings align with reports that use other measures to determine comparability between associate clinicians and physicians attending cesarean births. A review of 1134 complicated births in Tanzanian district hospitals reported no significant differences between assistant medical officers and physicians in terms of outcomes, risk indicators or quality [16]. The results were likewise comparable in Malawi [32], Mozambique [21, 33] and Sierra Leone [17].

Associate clinicians are more likely than physicians to accept and embrace work in rural, remote and underserved areas. In one survey of medical students in six African countries, only 4.8% intended to practice in rural areas, revealing misalignment between medical student intentions and health workforce needs [34]. A study in Mozambique reported that no physicians remained in rural areas 7 years after graduation, in contrast to 88% retention among associate clinicians [35]. The training and deployment of associate clinicians are less expensive than the training and deployment of physicians, so cesarean sections performed by associate clinicians are comparatively less expensive for the health system [36, 37].

Associate clinicians perform the majority of obstetric surgeries in Tanzania and Malawi. According to a survey of 38 district hospitals in Malawi, associate clinicians performed 90% of cesarean sections, 89% of uterine rupture repairs and 60–70% of CS/hysterectomies [32]. According to a survey of 14 hospitals in Kigoma and Mwanza, Tanzania, associate clinicians performed 92% of obstetric surgeries in government hospitals and 73% in mission hospitals [16]. Associate clinicians perform approximately 90% of cesarean sections at district level in Mozambique [21]. In this light, it is unsurprising that associate clinicians performed 86.7% of the cesarean births reported by women who later sought fistula repair. Urogenital fistulas occur most commonly in rural, underserved areas where women do not have sufficient access to emergency obstetric care [38].

Health providers from both cadres attended cesarean births resulting in iatrogenic injury. As previously reported, one-quarter of women with fistulas following cesarean birth had an injury caused by surgery rather than prolonged, obstructed labor [25]. In that analysis, the reported proportions of iatrogenic fistulas after cesarean birth were lower in Tanzania (25.0%) and Malawi (25.9%) than in neighboring countries where associate clinicians do not perform cesarean sections, including Rwanda (26.0%), Kenya (28.8%) and Uganda (30.2%). In contrast to these neighbors, in Tanzania and Malawi the increase in iatrogenic fistulas over time was less than would be expected from the increasing frequency of cesarean section as a mode of birth reported by women who later presented for fistula repair [25].

Although the occurrence of iatrogenic fistulas was lower in cesarean births attended by associate clinicians (24.6%) than those attended by physicians (29.2%), it is not known whether the cadres have fundamentally different cesarean caseloads. One would anticipate that more difficult and complex caseloads would correspond to an increased risk of iatrogenic injury. Associate clinicians are frequently the health professionals available to provide emergency obstetric care in remote, rural locations where physicians are not present.

The proportion of iatrogenic fistulas among women who undergo fistula repair appears to be on the rise in low- and middle-income countries [39]. We previously reported that 26.8% of women with fistulas following cesarean birth had an injury caused by their surgery in a nine-country analysis that included these women in Tanzania and Malawi [25]. Among 229 women with fistulas following cesarean birth in the Democratic Republic of the Congo, 24.0% had iatrogenic injuries [40]. In Ethiopia, a review of 2593 women with fistulas reported that 24.6% had “high bladder fistula (predominantly after surgery.)” [41]. High fistulas similarly accounted for 26.3% (119/452) of vesico-vaginal fistulas in Malawi, “likely due to operative injury rather than obstructed labor.” [42]. Taken together, the evidence supports generalizability of our findings on the proportion of iatrogenic fistulas among women who presented for fistula repair after cesarean birth in Malawi and Tanzania.

Task shifting for emergency obstetric surgeries has long been a subject of investigation [43]. Beyond the comparability of clinical outcomes, compared with physicians, associate clinicians demonstrate superior retention and cost-effectiveness (in training and deployment) [21, 37]. One Mozambican study reported that health workers at all levels expressed satisfaction with the work of associate clinicians, while noting challenges with their professional status and remuneration [44]. Although task shifting to associate clinicians can be an important component in caring for women’s needs for emergency obstetric care, particularly where physicians are scarce, in many countries challenges continue with physicians’ acceptance of associate clinicians providing cesarean sections [22].

Although the adjusted odds ratios for associate clinicians were not statistically significant, it is remarkable that the adjusted odds ratio in Tanzania mirrored the overall (combined) adjusted odds ratio, while the adjusted odds ratio in Malawi differed directionally. This may reflect the smaller sample size in Malawi. It is also possible that physician and associate clinician performance differ between the two countries.

The equivalence margin, δ, is defined as the maximum acceptable difference in iatrogenic fistula occurrence that one is willing to accept in return for the secondary benefits of associate clinicians providing cesarean sections [45]. The equivalence margin in this analysis was set to 13.5%: iatrogenic fistulas following cesarean birth should be no more than 13.5% more frequent in births attended by associate clinicians than in births attended by physicians. At that equivalence margin in this sample of women who presented for fistula repair after cesarean section, associate clinicians were found to be equivalent to physicians in terms of iatrogenic fistula occurrence in cesarean birth.

Strengths and limitations

Although this retrospective records review included a large number of fistulas following cesarean birth, it is not without limitations. All women in this study developed fistulas and sought treatment, and their experiences may differ from those who died from unattended obstructed labor, women who developed fistulas but did not seek treatment, and women who were spared a fistula through appropriate management of prolonged labor. We did not have records from women who had cesarean births and did not develop fistulas. We do not have a reason to doubt that the included women were representative of all women seeking fistula treatment in the two countries, although selection bias is possible particularly in Malawi, given its smaller sample size. We minimized variability by having a single surgeon confirm the fistula classifications.

We relied on self-reported information from women about their birth experiences, including the condition of their babies. In many cases, years passed between the day of birth and when the woman presented for fistula repair. We acknowledge that women’s recollection of childbirth may differ from how healthcare providers diagnose obstetric problems. To minimize bias, we excluded fistulas that occurred before the start date of our data collection. At the end of our study period, however, it is possible that long-duration fistulas were underrepresented. Given that this review included women who presented for fistula repair after cesarean birth, it may include cesarean sections performed for indications other than prolonged, obstructed labor. As with all retrospective studies, inferences must focus on associations rather than causation.

This review includes more records from Tanzania than Malawi given the differing volumes of fistula repairs conducted by TJIPR, MM, and colleagues. TJIPR’s determination of the cadre attending birth was dependent on his and his colleagues’ knowledge of local facilities and their staffing, which could be subject to recall bias and may be difficult for others to reproduce.

A narrower equivalence margin would provide more definitive evidence of equivalence. Given that only 13% of the included cesarean births resulting in fistulas were attended by physicians, the sample size was insufficiently powered to detect smaller differences between associate clinicians and physicians. Future investigations into the comparability of associate clinicians and physicians may include greater numbers of physician-attended cesarean births, leading to greater statistical power.

Despite these limitations, the equivalence between associate clinicians and physicians attending cesarean births in Tanzania and Malawi provides compelling evidence on the success of cesarean task shifting programs.

Conclusions

The occurrence of iatrogenic fistulas illustrates the importance of appropriate labor management and cesarean section decision-making, irrespective of the health provider cadre. The high proportion of iatrogenic fistulas among women who present with fistulas after cesarean birth must compel action to improve labor management and surgical safety.

More research is needed to understand associate clinician training, supervision and performance in countries where associate clinicians perform cesarean sections. This can then be compared to medical officer training, supervision and performance in countries where only physicians perform cesarean sections. Such investigations might shape future policy decisions regarding cadre roles. With sufficient evidence, the hallmarks of successful training, supervision and mentorship programs can be applied across cadres and international boundaries.

Given the equivalent performance and the lower cost of training and retaining associate clinicians in rural areas, other countries with insufficient and/or unequally distributed health workforces could consider task-shifting cesarean sections to associate clinicians.

Availability of data and materials

The data set analyzed during the current study is available from the corresponding author upon reasonable request.

References

  1. Alkema L, Chou D, Hogan D, Zhang S, Moller A-B, Gemmill A, et al. Global, regional, and national levels and trends in maternal mortality between 1990 and 2015, with scenario-based projections to 2030: a systematic analysis by the UN Maternal Mortality Estimation Inter-Agency Group. Lancet. 2016;387:462–74.

    Article  PubMed  Google Scholar 

  2. Musarandega R, Nyakura M, Machekano R, Pattinson R, Munjanja SP. Causes of maternal mortality in Sub-Saharan Africa: a systematic review of studies published from 2015 to 2020. J Glob Health. 2021;11:04048.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Paxton A, Maine D, Freedman L, Fry D, Lobis S. The evidence for emergency obstetric care. Int J Gynaecol Obstet. 2005;88:181–93.

    Article  CAS  PubMed  Google Scholar 

  4. Betrán AP, Ye J, Moller A-B, Zhang J, Gülmezoglu AM, Torloni MR. The increasing trend in caesarean section rates: global, regional and national estimates: 1990–2014. PLoS ONE. 2016;11: e0148343.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Ye J, Zhang J, Mikolajczyk R, Torloni MR, Gülmezoglu AM, Betran AP. Association between rates of caesarean section and maternal and neonatal mortality in the 21st century: a worldwide population-based ecological study with longitudinal data. BJOG. 2016;123:745–53.

    Article  CAS  PubMed  Google Scholar 

  6. Silver RM. Implications of the first cesarean: perinatal and future reproductive health and subsequent cesareans, placentation issues, uterine rupture risk, morbidity, and mortality. Semin Perinatol. 2012;36:315–23.

    Article  PubMed  Google Scholar 

  7. Motomura K, Ganchimeg T, Nagata C, Ota E, Vogel JP, Betran AP, et al. Incidence and outcomes of uterine rupture among women with prior caesarean section: WHO Multicountry Survey on Maternal and Newborn Health. Sci Rep. 2017;7:44093.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Dekker L, Houtzager T, Kilume O, Horogo J, van Roosmalen J, Nyamtema AS. Caesarean section audit to improve quality of care in a rural referral hospital in Tanzania. BMC Pregnancy Childbirth. 2018;18:164.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Sandall J, Tribe RM, Avery L, Mola G, Visser GH, Homer CS, et al. Short-term and long-term effects of caesarean section on the health of women and children. Lancet. 2018;392:1349–57.

    Article  PubMed  Google Scholar 

  10. Bishop D, Dyer RA, Maswime S, Rodseth RN, van Dyk D, Kluyts H-L, et al. Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study. Lancet Glob Health. 2019;7:e513–22.

    Article  PubMed  Google Scholar 

  11. Weiser TG, Haynes AB, Molina G, Lipsitz SR, Esquivel MM, Uribe-Leitz T, et al. Size and distribution of the global volume of surgery in 2012. Bull World Health Organ. 2016;94:201–9.

    Article  PubMed  PubMed Central  Google Scholar 

  12. World Health Organization. The state of the health workforce in the WHO African region. Brazzaville: WHO Regional Office for Africa; 2021.

    Google Scholar 

  13. Ahmat A, Okoroafor SC, Kazanga I, Asamani JA, Millogo JJS, Illou MMA, et al. The health workforce status in the WHO African Region: findings of a cross-sectional study. BMJ Glob Health. 2022;7: e008317. https://doi.org/10.1136/bmjgh-2021-008317.

    Article  PubMed  PubMed Central  Google Scholar 

  14. Willcox ML, Peersman W, Daou P, Diakité C, Bajunirwe F, Mubangizi V, et al. Human resources for primary health care in sub-Saharan Africa: progress or stagnation? Hum Resour Health. 2015;13:76.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Mullan F, Frehywot S. Non-physician clinicians in 47 sub-Saharan African countries. Lancet. 2007;370:2158–63.

    Article  PubMed  Google Scholar 

  16. McCord C, Mbaruku G, Pereira C, Nzabuhakwa C, Bergstrom S. The quality of emergency obstetrical surgery by assistant medical officers in Tanzanian district hospitals. Health Aff. 2009;28:w876–85.

    Article  Google Scholar 

  17. van Duinen AJ, Kamara MM, Hagander L, Ashley T, Koroma AP, Leather A, et al. Caesarean section performed by medical doctors and associate clinicians in Sierra Leone. Br J Surg. 2019;106:e129–37.

    Article  PubMed  Google Scholar 

  18. Bolkan HA, van Duinen A, Waalewijn B, Elhassein M, Kamara TB, Deen GF, et al. Safety, productivity and predicted contribution of a surgical task-sharing programme in Sierra Leone. Br J Surg. 2017;104:1315–26.

    Article  CAS  PubMed  Google Scholar 

  19. Raassen TJIP, Ngongo CJ, Mahendeka MM. Iatrogenic genitourinary fistula: an 18-year retrospective review of 805 injuries. Int Urogynecol J. 2014;25:1699–706.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Trends in maternal mortality 2000 to 2020: estimates by WHO, UNICEF, UNFPA, World Bank Group and UNDESA/Population Division. Geneva: World Health Organization; 2023.

  21. Bergström S. Training non-physician mid-level providers of care (associate clinicians) to perform caesarean sections in low-income countries. Best Pract Res Clin Obstet Gynaecol. 2015;29:1092–101.

    Article  PubMed  Google Scholar 

  22. Bergström S, McPake B, Pereira C, Dovlo D. Workforce innovations to expand the capacity for surgical services. In: Debas HT, Donkor P, Gawande A, Jamison DT, Kruk ME, Mock CN, editors. Essential surgery: disease control priorities, vol. 1. 3rd ed. Washington: The International Bank for Reconstruction and Development/The World Bank; 2016.

    Google Scholar 

  23. Ngongo CJ, Raassen T, Lombard L, van Roosmalen J, Weyers S, Temmerman M. Delivery mode for prolonged, obstructed labour resulting in obstetric fistula: a retrospective review of 4396 women in East and Central Africa. BJOG. 2020;127:702–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Fistula Care Plus. Iatrogenic fistula: an urgent quality of care challenge. 2016. https://fistulacare.org/wp-content/uploads/2016/04/Iatrogenic-fistula-technical-brief_2016.pdf. Accessed 1 Apr 2024.

  25. Ngongo CJ, Raassen TJIP, Mahendeka M, Lombard L, van Roosmalen J. Iatrogenic genito-urinary fistula following cesarean birth in nine sub-Saharan African countries: a retrospective review. BMC Pregnancy Childbirth. 2022;22:541.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Ngongo CJ, Raassen TJIP, Mahendeka M, Lombard L, van Roosmalen J, Temmerman M. A retrospective review of genital fistula occurrence in nine African countries. BMC Pregnancy Childbirth. 2022;22:744.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Ngongo C. Epidemiology and etiology of genital fistulas in Eastern Africa. Ghent University; 2023. https://biblio.ugent.be/publication/01GRNFWAF92R70GATGEVWAT1P4. Accessed 19 Jul 2023.

  28. Waaldijk K. Surgical classification of obstetric fistulas. Int J Gynaecol Obstet. 1995;49:161–3.

    Article  CAS  PubMed  Google Scholar 

  29. Raassen TJIP, Ngongo CJ, Mahendeka MM. Diagnosis and management of 365 ureteric injuries following obstetric and gynecologic surgery in resource-limited settings. Int Urogynecol J. 2018;29:1303–9.

    Article  PubMed  Google Scholar 

  30. Dixon PM, Saint-Maurice PF, Kim Y, Hibbing P, Bai Y, Welk GJ. A primer on the use of equivalence testing for evaluating measurement agreement. Med Sci Sports Exerc. 2018;50:837–45.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Barker LE, Luman ET, McCauley MM, Chu SY. Assessing equivalence: an alternative to the use of difference tests for measuring disparities in vaccination coverage. Am J Epidemiol. 2002;156:1056–61.

    Article  PubMed  Google Scholar 

  32. Chilopora G, Pereira C, Kamwendo F, Chimbiri A, Malunga E, Bergström S. Postoperative outcome of caesarean sections and other major emergency obstetric surgery by clinical officers and medical officers in Malawi. Malawi Med J. 2016;28:94–8.

    PubMed  PubMed Central  Google Scholar 

  33. Pereira C, Bugalho A, Bergström S, Vaz F, Cotiro M. A comparative study of caesarean deliveries by assistant medical officers and obstetricians in Mozambique. Br J Obstet Gynaecol. 1996;103:508–12.

    Article  CAS  PubMed  Google Scholar 

  34. Burch VC, McKinley D, van Wyk J, Kiguli-Walube S, Cameron D, Cilliers FJ, et al. Career intentions of medical students trained in six sub-Saharan African countries. Educ Health. 2011;24:614.

    Article  CAS  Google Scholar 

  35. Pereira C, Cumbi A, Malalane R, Vaz F, McCord C, Bacci A, et al. Meeting the need for emergency obstetric care in Mozambique: work performance and histories of medical doctors and assistant medical officers trained for surgery. BJOG. 2007;114:1530–3.

    Article  CAS  PubMed  Google Scholar 

  36. Anyangwe SCE, Mtonga C. Inequities in the global health workforce: the greatest impediment to health in sub-Saharan Africa. Int J Environ Res Public Health. 2007;4:93–100.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Kruk ME, Pereira C, Vaz F, Bergström S, Galea S. Economic evaluation of surgically trained assistant medical officers in performing major obstetric surgery in Mozambique. BJOG. 2007;114:1253–60.

    Article  CAS  PubMed  Google Scholar 

  38. Donnay F, Ramsey K. Eliminating obstetric fistula: progress in partnerships. Int J Gynaecol Obstet. 2006;94:254–61.

    Article  CAS  PubMed  Google Scholar 

  39. Hilton P. Trends in the aetiology of urogenital fistula: a case of “retrogressive evolution”? Int Urogynecol J. 2016;27:831–7.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Onsrud M, Sjøveian S, Mukwege D. Cesarean delivery-related fistulae in the Democratic Republic of Congo. Int J Gynaecol Obstet. 2011;114:10–4.

    Article  PubMed  Google Scholar 

  41. Wright J, Ayenachew F, Ballard KD. The changing face of obstetric fistula surgery in Ethiopia. Int J Womens Health. 2016;8:243–8.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Kopp DM, Sih AM, Tang JH, Rosenberg NE, Chipungu E, Chiudzu G, et al. 255: Delivery factors associated with fistula location among Malawian women. Am J Obstet Gynecol. 2016;214:S149–50.

    Article  Google Scholar 

  43. Hoyler M, Hagander L, Gillies R, Riviello R, Chu K, Bergström S, et al. Surgical care by non-surgeons in low-income and middle-income countries: a systematic review. Lancet. 2015;385(Suppl 2):S42.

    Article  PubMed  Google Scholar 

  44. Cumbi A, Pereira C, Malalane R, Vaz F, McCord C, Bacci A, et al. Major surgery delegation to mid-level health practitioners in Mozambique: health professionals’ perceptions. Hum Resour Health. 2007;5:27.

    Article  PubMed  PubMed Central  Google Scholar 

  45. Walker E, Nowacki AS. Understanding equivalence and noninferiority testing. J Gen Intern Med. 2011;26:192–6.

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank the specialists and staff in the hospitals. The African Medical and Research Foundation (AMREF), EngenderHealth, the Fistula Foundation, the Freedom from Fistula Foundation, Gesellschaft für Technische Zusammenarbeit (GTZ; now GIZ), Johnson & Johnson, the Royal Netherlands Embassy of Tanzania, SOS East Africa, the United Nations Population Fund (UNFPA), and Women and Health Alliance International (WAHA) generously supported travel to the many hospitals for TJIPR and MM. Millicent Oundo entered some of the data through the support of the United States Agency for International Development through EngenderHealth's Fistula Care project. We are grateful to RTI International for professional development award support. We thank the International Federation of Gynecology and Obstetrics (FIGO) for paying the article processing charge. Finally, we thank the women whose unforgettable experiences informed our conclusions.

Funding

RTI International supported Carrie Ngongo’s time in finalizing the analysis and manuscript.

Author information

Authors and Affiliations

Authors

Contributions

CJN and TJIPR designed the study and interpreted the data. TJIPR and MM collected the data. EB advised on the analysis approach and framing. CJN developed the data coding, analyzed the data, developed the tables and figures, and drafted the manuscript. LL conducted the literature searches and entered data. JvR provided guidance and edited the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Carrie J. Ngongo.

Ethics declarations

Ethics approval and consent to participate

AMREF Ethics and Scientific Review Committee P88/2013.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ngongo, C.J., Raassen, T.J.I.P., van Roosmalen, J. et al. Equivalence between physicians and associate clinicians in the frequency of iatrogenic urogenital fistula following cesarean section in Tanzania and Malawi. Hum Resour Health 22, 43 (2024). https://doi.org/10.1186/s12960-024-00927-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1186/s12960-024-00927-8

Keywords